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Marijuana can cause adverse reactions with any medication, because it's not a legal substance, and therefore hasn't been tested with medications.
It CAN react badly with your pills, depending on what you are on. Your best bet is to discuss it with your doctor- they can only help you if they know what you are doing.
On the other hand, marijuana can be an antidepressant all on it's own, and can help with your sleeping problem. I take Lunesta for sleeping, it's a wonderful drug.
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