I know when my Grandma was going thru cancer treatments (half anf half chemo/radiation) the week that she was going through the treatment it wouldn't effect her as much, but the week after she would be very fatigued/sick...I believe its the drugs that they give you the side effects are loss of appetite/vomiting...it was horrible because she had stomach cancer so she wasn't really into eatting anyways...I'd have to watch her to make sure she'd eat some toast and have some water...there was a while there where it felt like everytime we turned around we were taking her to the hospital for de-hydration because she would refuse food and water for days on end.
Luckily she's in remission and is doing MUCH better!